The dietary antioxidant

ErgoActive® ergothioneine — an antioxidant your cells collect.

Ergothioneine is an antioxidant found in foods like mushrooms. Your body can’t make it, but your cells have a dedicated transporter to take it in and hold on to it. ErgoActive® is the same molecule, made by fermentation.

ErgoActive® · Blue California, California, USA · L-ergothioneine by fermentation

ErgoActive® · Blue California · L-ergothioneine

Measured in the blood, week by week.

In a 16-week study, adults aged 55–79 took 10 mg, 25 mg or a placebo each morning with food. At 10 mg, blood ergothioneine was about three times its starting level by week 4 and about six times by week 16, while the placebo group stayed flat.

10 mgper capsule — the lower of the two doses in its 16-week study
~3×blood ergothioneine by week 4 at 10 mg, in adults aged 55–79
~6×by week 16, the study’s last timepoint

What it’s for

  • A dietary antioxidantErgothioneine comes from food, and your cells take it up through a transporter of their own.
  • Helps maintain ergothioneine levelsAt our 10 mg, blood ergothioneine rose steadily over 16 weeks in a maker-supported placebo-controlled study.
  • Made by fermentationErgoActive® is produced by fermentation and purified — not extracted from mushrooms.
  • VeganBlue California certifies ErgoActive® as vegan.

What researchers measured — at our 10 mg dose

ErgoActive® · RDBPC

Sixteen weeks of ergothioneine

147 adults aged 55–79 with self-reported memory complaints · randomized, double-blind, placebo-controlled · 10 or 25 mg a day · 16 weeks · Nutraceuticals, 2025

~3×blood ergothioneine at week 4, 10 mg group
~6×at week 16, still rising
Noneadverse events attributed to ergothioneine

Zajac et al., Nutraceuticals 2025;5(3):15, doi:10.3390/nutraceuticals5030015. Funded by Blue California (maker-supported). A study of the ingredient, not of this finished product.

The same study measured memory, reaction time and sleep. At 10 mg there were no clear differences from placebo; the effects it reported were at 25 mg. So we make no memory or sleep claim for ErgoActive®.

L-ergothioneine. These structure/function statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Cited research is of the ingredient at the dose named, not this finished formula. Photography shows mushrooms, a food source of ergothioneine, not the capsule.